两种不同给药法对降低颅内压增高效果的观察

Observation on the Therapeutic Effect on Intracranial Hypertension by Two different Administration R

摘要: 治疗脑出血并颅内压增高患者，传统给药法是静脉快速滴注２０％甘露醇２５０～５００ｍｌ，但由于血容量骤增和药物对肾脏有不同程度损害，心、肾功能不全者禁用。为此，我们采用了颈动脉给药法，每次６０～１００ｍｌ，４～６小时一次。自１９９３年３月～１９９７年１２月，将１００例脑出血并高颅压患者随机分为治疗组和对照组，每组５０例。实验结果证明：Ｐ＜０．０５，两组有明显差异。治疗组由于采用颈动脉给药法，药液直接进入脑动脉循环，途径短、作用快，降频压效果好，且对心、肾功能不全的患者均可使用。

Abstract: The traditional administration rute,20% Mannitol,250～500ml intravenous dripped abruptly, was used to treat the patients with encephalorrage and intracranial hypertension,but it was contraindicated for the patients with heart and renal insufficiency due to damaged in varying degrees caused by increasing blood volume adruptly and the drug effect on kidney. For this reason, 60 to 100mL once every four to six hours was adopted by carotid administration rute. One hundred cases with cerebral hemorrhage and intra...