Abstract: To assess whether MT-Ⅲ is able to prevent glutamate and Aβ nerve toxicity.We infected the rat cerebral cortical neurons in culture with MT-Ⅲ cDNA recombinant adenovirus constructed in our laboratory,The results of MTT assays and PI-Hochest(33342) staining revealed that the expression of MT-Ⅲ significantly increased the relative percentage of surviving neurons treated by glutamate and Aβ.The Western blot analysis indicated that in the apoptotic pathway induced by glutamate,MT-Ⅲ protected neurons by interfer...