Abstract: The electrochemical behavior of the interaction of sulfadiazine and DNA at pH 2.21 was investigated by voltammograms.The peak current and peak potential of sulfadiazine changed after the addition of DNA.The ultraviolet spectroscopic results suggest that an electrochemical inactive supramolecular complex was formed due to the reaction of sulfadiazine and DNA.The interaction between sulfadiazine and DNA is electrostatic attraction in nature.The binging constant Kb of the supramolecular complex is 4.6×103 L·mo...