Abstract: Ranolazine is a novel anti-angina drug with brightly applicable prospect,but obstacles for the application of ranolazine include hard operation conditions,high piperazine consumption and low yield,etc.in the syntheses reported in literatures.Ranolazine was synthesized with 2,6-dimethyl aniline as starting precursor.Monohydrochloride piperazine was used instead of piperazine for the synthesis of N-(2,6-dimethylbenzyl)-1-piperazinylacetamine,resulting in decreased piperazine consumption.Reaction conditions su...