β-四(4-羧基苯氧基)酞菁锌的合成与抗肿瘤活性研究

Study on Synthesis and Antineoplastic Activity of β-tetra-(p-carboxyphenoxy) phthalocyanine Zinc

摘要: 通过两步合成了两亲性的β-四(4-羧基苯氧基)酞菁锌(Ⅱ),采用UV-Vis、IR、元素分析、激光解吸电离飞行时间质谱(TOF-MS)对配合物进行了表征.在光诱导条件下,采用四甲基偶氮唑蓝比色法(MTT法),研究了此酞菁锌配合物对Bel-7402细胞抑制作用,考察了浓度对配合物的抑瘤效果的影响,确定其IC50值,结果发现:在光诱导条件下,酞菁锌配合物的适宜浓度具有较高的抑制率,并探讨了其抑瘤机理.

Abstract: A novel water soluble β-tetra-(p-carboxyphenoxy)phthalocyanine zinc(Ⅱ)has been synthesized in two-step.It was characterized by UV-vis absorption spectrum,IR spectrum,elemental analysis and TOF-MS.The damaging effects of phthalocyanine complexe on human Bel-7402 liver cancer cell were investigated by means of HE dye method and MTT colorimetric assay under photoinduce.The influences of the concentration of phthalocyanine complex on cancer inhibition were systemically studied and IC50 value was ascertained.The...