Abstract: Houttuynia Thunb. is a commonly used medicinal and edible homologous medicinal material in clinical practice. The relevant research progress on Houttuynia cordata Thunb. was summarized in the treatment of lung cancer at home and abroad based on its good anti-inflammatory， anti-tumor， and immune regulatory activities， and the potential mechanisms of Houttuynia cordata Thunb. against lung cancer such as inhibiting the invasion and migration of lung cancer cells， arresting the cell cycle of lung cancer cells， inducing autophagy of lung cancer cells， mediating apoptosis of lung cancer cells， inhibiting angiogenesis， inhibiting oxidative stress， enhancing the immune function of the body， improving the inflammatory response of pneumonia， and enhancing the sensitivity of lung cancer cells to radiotherapy and chemotherapy， with a view to providing relevant references and guidance for the further research and application of Houttuynia cordata Thunb. in the biomedical field.