Abstract: Water⁃soluble UV absorbers containing reactive groups were obtained by hydrophilic modification of UV absorber derivatives containing benzophenone structures as raw materials. The structure and toxicity of the water‑soluble UV absorbers were characterized by nuclear magnetic resonance （NMR）， Fourier infrared spectroscopy （FTIR）， X‑ray photoelectron spectroscopy （XPS） and toxicology experiments. The experimental results showed that the water⁃soluble UV absorbers had good UV resistance and contain non‑toxic properties. In addition， water⁃soluble UV absorbers were applied to hydrogel to produce UV‑resistant hydrogel， and their UV absorption and transmittance were tested. The experimental results showed that the prepared hydrogel had higher UV resistance and visible light transmission than commercially available UV resistant contact lenses.