Abstract: The MXene (MX) sheet obtained by chemical etching has a large number of anionic functional groups. Based on the spray drying technology, the MXene modified by vanadium ion (MX-VN) material was designed and synthesized for the cathode of lithium-sulfur batteries (LSBs). The excellent conductivity of MXene could improve the overall conductivity of the sulfur cathode. At the same time, the in-situ constructed MX-VN interface could improve the adsorption effect and catalytic ability of polysulfides, meanwhile improve the utilization rate of sulfur. The experimental results showed that the discharge capacity of the LSBs with MX-VN/S as the cathode was as high as 1438 mAh/g at 0.1 C, and the capacity retention rate was as high as 77.5% after 200 cycles at 0.5 C. The performance of the battery was significantly improved.