Abstract: Based on the temperature data derived from 19 meteorological stations in Henan province from 1970 to 2019, the data of sea surface temperature anomaly (SSTA), and the southern oscillation index (SOI), the mathematical statistics methods were used to analyze spatial-temporal characteristics of climate change of Henan province, and its correlation with El Niño-Southern Oscillation (ENSO) event. The results showed that: (1) The annual and seasonal temperature of Henan province showed the significant fluctuation and rising tendency from 1970 to 2019, and the annual temperature increased at a rate of 0.24℃/10a. Meanwhile, the spring temperature increased at the highest rate, while the winter temperature increased at the lowest rate. (2) There was a correlation relationship between the ENSO events intensity and temperature change during the past 50 years in Henan province. And since the 1990s, with the increase and intensity of El Niño events, the temperature has also increased significantly in this region. (3) In the ENSO event years, there is a significant correlation between the temperature change and SSTA values in Henan province, both with a certain lag of time.Therefore, the extreme meteorological disasters are likely to occur in strong ENSO event years or the following year in the Henan province, so the vigilant and strengthen prevention should be taken.