2022年诺贝尔化学奖解读——点击化学和生物正交化学

Introduction of the 2022 Nobel Prize in Chemistry: Click Chemistry and Bioorthogonal Chemistry

摘要: 2022年诺贝尔化学奖授予美国化学家卡尔·巴里·夏普利斯(K. Barry SHARPLESS)、丹麦化学家摩顿·梅尔达尔(Morten MELDAL) 和美国化学家卡罗琳·贝尔托西(Carolyn R. BERTOZZI), 以表彰他们为发明和发展点击化学和生物正交化学所做出的突出贡献。详细介绍了点击化学和生物正交化学在生物学科领域中的应用, 并展望了其在化学学科和生物学科领域面临的新挑战和新机遇。点击化学和生物正交化学是人类探究生物化学过程本质的高效分子水平构建工具。

Abstract: The 2022 Nobel Prize in Chemistry has been awarded to American chemist K. Barry SHARPLESS, Danish chemist Morten MELDAL, and American chemist Carolyn R. BERTOZZI, in recognition of their outstanding contributions to the invention and development of click chemistry and bioorthogonal chemistry. The application of click chemistry and bioorthogonal chemistry in biology is presented in detail, and the new challenges and opportunities in the fields of chemistry and biology are envisioned. An efficient molecular construction tool for human is provided to explore the nature of biochemical processes.