Abstract: In order to solve the problem of sand resources for concrete and the limitation of traditional curing methods in dealing with the freezing environment, the freeze-thaw cycle test was carried out with the slow freezing method on the specimens formed by desalinated sea sand, mechanism sand and mixed sand, and the freezing resistance performance under standard curing conditions was explored. The experimental results showed that the frost resistance performance of the formed mixed sand specimens was better than that of single sand when the ratio of desiccated sea sand and mechanism sand was 6:4. In addition, to address the limitations of the conventional curing methods, four parallel curing methods were applied to the mixed sand specimens to compare their frost resistance performance, and the internal samples of the parallel specimens were taken at the curing age of 28 d. The microstructure was investigated and analyzed by SEM. The results showed that the loss rate of compressive strength of the mixed sand specimens with external curing was low, but the change of porosity after freeze-thaw was large, which indicates that it performs better in low number of freeze-thaw cycles; the change of porosity of the mixed sand specimens with internal curing was small after freeze-thaw cycles, which can effectively control the pore development, but its own compressive strength was slightly lower; when both curing methods were used, the mass, compressive strength loss rate and porosity increase of the mixed sand specimens were smaller after freeze-thaw cycles, and the less cracks were also observed in the result analysis of SEM microstructure, and the compressive strength could reach the level of standard maintenance.