Abstract: Based on the high resolution temperature proxy series over the Qinghai-Tibet Plateau during the past two millennia, the spatial and temporal characteristics of temperature changes over the Qinghai-Tibet Plateau are analyzed by regional correlation and integrated analysis. The results reveal that temperature changes during the past two millennia can be categorized into four centennial-scale cold and warm periods: cold intervals in 0-600 AD and 1400-1900 AD, as well as warm intervals in 600-1400 AD and the twentieth century. The time periods of 1400-1900 AD and 600-1400 AD correspond to the Little Ice Age and the Medieval Warm Period in Europe, respectively. Temperature variations on the Tibetan Plateau over the past two millennia are not uniform and exhibit strong seasonality. While the patterns of mean annual temperature change on the plateau during this period remain inconclusive, summer temperature fluctuations generally display consistency.The summer temperature reconstructions suggest that the warmest period of the past two millennia occurred during the Middle Ages, rather than in the recent 20th century. Currently, the climate records on the Tibet Plateau during the late Holocene are still scarce. Seasonal bias, applicability of the transfer function, and chronological error might cause uncertainty in temperature reconstruction records. It is crucial to develop high-quality quantitative paleotemperature series with clear seasonality, site-specific proxy-temperature calibration, and better chronologic constraints in order to further reveal the spatio-temporal pattern and mechanism of temperature change on the Tibetan Plateau.