Abstract: Based on a coupled thalamocortical mean field model, the inhibitory projection of thalamic reticular nucleus to the relay nucleus and time delay resulting from the projection are used as pathological factors to investigate the effect of the slow dynamics of GABA_B receptors in the thalamic reticular nucleus on epileptic discharges. On the one hand, with the change of inhibitory coupling strength from the thalamic reticular nucleus to the relay nucleus, when the time delay is large enough, the spike and wave discharges and 2-spike and wave discharges are generated in both compartments Ⅰ and Ⅱ. There are more types of dynamical states in compartment Ⅰ and fewer epilepsy areas in compartment Ⅱ. On the other hand, by exploring the state analysis of the above two pathological factors, it is concluded that the correlation between time delay and epilepsy is stronger. When the time delay is large enough, it is easier to induce the spike and wave discharges and poly-spike and wave discharges in both compartments Ⅰ and Ⅱ.