Abstract: From the tourist resources endowment, regional economic development level, tourism facilities and ecological environmental quality, the influence factors of urban tourism spatial differentiation in the Yellow River and its interaction are analyzed by using the geographical probe. The results show that: (1) Urban tourism economy space differentiation in the Yellow River is obvious, tourism revenues vary widely between provinces and cities. The total tourism revenue in southeast of the Yellow River basin is higher than that in northwest. (2) The factor detector shows that the number of star hotels, the number of scenic spots, the number of cultural landscape, the per capita GDP of city, road network density, PM2.5, the proportion of tertiary industry, the number of natural landscape and the per capita park green area have the significant impact on tourism economy. The impact degree decreases successively, and the interaction effect between the factors is obvious. (3) The spatial law of the influence of each factor on tourism economy is not the same. Except for the relatively fragmented influence of PM2.5 concentration on regional tourism revenue, the influence of other factors basically shows an increasing or decreasing trend in the east-west direction or from the center to both ends.