Abstract: A SEIARV model with asymptomatic infection and saturation incidence rate is studied. The basic reproduction number is defined, and the existence and local stability of equilibrium are obtained. By constructing Lyapunov function, it is proved that the disease-free equilibrium is globally asymptotically stable when the basic reproduction number R₀ < 1. When R₀>1, the endemic equilibrium is globally asymptotically stable.