Abstract: The spatio-temporal evolution characteristics and driving mechanism of the agriculture-tourism integration efficiency in Henan Province from 2010 to 2019 areexplored by using DEA benevolent cross-efficiency model and geographical detector. The results show that the overall level of the agriculture-tourism integration efficiency in the past ten years is relatively good, and display the obvious promotion efficiency of tourism to agriculture, but the promotion efficiency of agriculture to tourism is relatively low. Moreover, the spatial heterogeneity of agricultural-tourism integration efficiency is significant, and only 44% of the cities are characterized by high efficiency and stability. The regions with fluctuating efficiency have high potential for subsequent development. In addition, the hot and sub-hot spots show a spatial evolution pattern from dispersion to agglomeration, while the cold and sub-cold spots exhibit a spatial evolution pattern of dispersion. Finally, characteristic resources, economic development level and innovation ability are the main driving factors of spatial differentiation of agriculture-tourism integration efficiency.