Abstract: Alcoholic fatty liver disease, one of the most common liver diseases in the world, can develop into alcohol-related inflammation (hepatitis), alcohol-related fibrosis and eventually end-stage liver injury.Although the pathogenic factor of AFLD is single, the causes of the disease are complex, which are yet to be determined.It's found that acute or chronic ethanol exposure can cause hepatic steatosis in humans and rodents through a variety of cytokines interference by inhibition SIRT1, including AMPK, Lipin-1, SREBP-1, peroxisome proliferator β(PPARβ), auxiliary activator-1α(PGC-1α), forkhead transcription factor XO1 and adiponectin etc.Exercise training can induce the expression of SIRT1 in the body's motor system and non-motor system tissues.Activated SIRT1 can improve the decline of fatty acid oxidation rate, increase the fat synthesis rate and inflammation in AFLD under the influence of ethanol and its metabolites through a variety of ways.Based on the previous studies of the relationship between SIRT1 and the above-mentioned cytokines, combing with the current research of exercise and SIRT1, the research prospects of SIRT1 in the relationship between exercise and AFLD are prospected.