高肿瘤富集效率的钯金纳米片用于肿瘤光热治疗

Pd@Au Nanosheets with High Tumor Targeting Efficiency for Photothermal Therapy

  • 摘要: 以乙酰丙酮钯和三苯基膦氯化金为原料,合成平均对角线尺寸50 nm,厚度4 nm的六边形钯金纳米片,并进一步使用聚乙二醇表面修饰,获得Pd@Au-PEG纳米药物.Pd@Au-PEG表现出近红外吸收光谱(吸收峰840 nm)和较好的光热升温效果.研究了其在细胞水平的光热治疗性能,确认能够在808 nm激光照射下有效杀死癌细胞.进一步探究了其在小鼠各主要器官的组织分布情况,并发现其具有较高的肿瘤富集效率.最终在活体水平实现对实体肿瘤的光热治疗.

     

    Abstract: Pd@Au nanosheets with average diagonal size of 50 nm and thickness of 4 nm, were synthesized from Pd(acac)2 and AuCl(triphenylphosphine)3. Then Pd@Au-PEG nanodrug was obtained followeing by polyethylene glycol modification. Pd@Au-PEG showed strong near infrared absorption (peak at 840 nm) and good photothermal effect. The photothermal treatment performance at the cellular level was studied and it was verified that Pd@Au-PEG could kill cancer cells effectively under 808 irradiation. Tissue distribution in the main organs of mice was further explored, finding that it had a high tumor targeting efficiency. Effective photothermal treatment for solid tumors was finally realized in vivo.

     

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