Abstract: (-)-Epigallocatechin-3-gallate (EGCG), a major bioactive constituent in green tea, possesses anti-carcinogenic potential in different tumors. Recent data also showed that EGCG displayed its anti-cancer activity by targeting CSCs. This review focusses on the studies of EGCG functioned on characteristics, including migration and invasion, anti-chemotherapy, self-renewal and tumorigenicity. In addition, signaling pathways, including Wnt/β-catenin, Hedgehog, Notch and AKT pathways, involved in these progress were discussed to provide options for cancer and treatment.