Abstract: Aimed to the interaction of the frame-shear wall, the stiffness of isolation layer and stiffness ratio between frame and shear wall were analyzed for a 10-story high-rise frame-shear wall foundation isolation structure. The effect of seismic wave on the seismic response of high-rise frame-shear wall structure was studied by considering the filtering effect of seismic wave and considering the large displacement P-△ effect of the upper structure and the large displacement of the isolation layer. The results showed that, with the increase of the stiffness of the isolation layer, the amplitude of the acceleration spectrum was increased gradually at the bottom of the upper structure. As the stiffness ratio between the frame and the shear wall increases, the distribution of interlaminar shear tends to be uniform. The additional bending caused by the cumulative deformation of the superstructure was slightly larger than the additional bending moment produced by the P-△ effect of the isolation layer itself.