Abstract: Based on the abundant Buddhist architectures and cultures in Changdu, a regional cultural system of Tibetan Buddhism architecture was built. Meanwhile, by means of the comparative research on Buddhism architecture development history, site selection element, spatial form layout and architecture color utilization, and taking Changdu Karma Temple and Zizhu Temple as examples, it was concluded that the layout of Tibetan Buddhism temple was influenced by geographical as well as multi-cultural factors. All these were tried to provide some references for the design of Changdu modern Tibetan Buddhism temple.