Abstract: Target proteins of active compound of green tea (EGCG) related genes of breast cancer were searched from PubChem and Gene databases online respectively.Canonical pathways and molecular networks comparison analyses were performed by IPA. There were 235 common pathways in EGCG target proteins and breast cancer related gene, and top 4 shared signaling pathway are molecular mechanisms of cancer, inflammation signal pathway, glucocorticoid receptor signaling, NF-κB signaling; There were 5 common networks focused on post-translational modification and regulation, cell growth and development, DNA replication, recombination and repair, cell death and survival.