Abstract: The common-used open source CSerialPort class was improved, with the introduction of high precision multimedia timer in VS2013 environment, the batch UART data frame transceiver was implemented successfully, while for the instrumentation equipment, FTD232R of FTDI Chip Corp. was utilized to convert USB into virtual UART, and the maximum band rate attain 3Mb/s, which was 26 times than traditional strategy. XC6SLX16 FPGA of Xilinx Corp. was the instrumentation processing core, which completed UART frame transmitting/receiving and further processing. No specific interface card was adopted in whole system. Presented design has be used successfully for a smart antenna vector modulator array automated instrumentation, both transmission efficiency and robustness all preceded similar strategies remarkably.