荧光法研究阿托伐他汀钙与牛血清白蛋白的相互作用

吕艳阳, 张亚茹

吕艳阳, 张亚茹. 荧光法研究阿托伐他汀钙与牛血清白蛋白的相互作用[J]. 信阳师范学院学报(自然科学版), 2017, 30(2): 201-204. DOI: 10.3969/j.issn.1003-0972.2017.02.006
引用本文: 吕艳阳, 张亚茹. 荧光法研究阿托伐他汀钙与牛血清白蛋白的相互作用[J]. 信阳师范学院学报(自然科学版), 2017, 30(2): 201-204. DOI: 10.3969/j.issn.1003-0972.2017.02.006
LYU Yanyang, ZHANG Yaru. Interaction of Atorvastatin Calcium with Bovine Serum Albumin by Fluorescence[J]. Journal of Xinyang Normal University (Natural Science Edition), 2017, 30(2): 201-204. DOI: 10.3969/j.issn.1003-0972.2017.02.006
Citation: LYU Yanyang, ZHANG Yaru. Interaction of Atorvastatin Calcium with Bovine Serum Albumin by Fluorescence[J]. Journal of Xinyang Normal University (Natural Science Edition), 2017, 30(2): 201-204. DOI: 10.3969/j.issn.1003-0972.2017.02.006

荧光法研究阿托伐他汀钙与牛血清白蛋白的相互作用

基金项目: 

河南省教育厅自然科学基金项目(2011B150032)

国家自然科学基金项目(21305119)

详细信息
    作者简介:

    吕艳阳(1963-),女,河南信阳人,教授,主要从事分析化学研究.

  • 中图分类号: TS201.4

Interaction of Atorvastatin Calcium with Bovine Serum Albumin by Fluorescence

  • 摘要: 在不同温度下测定了阿托伐他汀钙(AC)对牛血清白蛋白(BSA)的荧光光谱的影响.结果表明,AC会使BSA发生荧光猝灭,随着AC浓度的增大,猝灭程度增强.AC对BSA的猝灭作用主要是动态猝灭,并计算得到AC与BSA的结合位点数为1.2.根据热力学方程式得出AC与BSA相互作用的参数,说明AC与BSA之间的相互作用力主要是疏水作用力.
    Abstract: The interaction between atorvastatin calcium(AC) and bovine serum albumin (BSA) was studied by fluorescence spectrum at different temperatures.The results showed that the fluorescence quenching of BSA was caused by AC. The degree of quenching was enhanced with the increase of the concentration of AC. The quenching belonged to dynamic quenching mostly. The binding sites of the AC and BSA was 1.2.The parameters of the interaction between AC and BSA were obtained according to the thermodynamic equation. The results indicated that the interaction between AC and BSA was mainly hydrophobic force.
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  • 期刊类型引用(2)

    1. 吕艳阳,张文生,袁广胜,陈越超,叶盈珊. 稀土钐离子与牛血清白蛋白相互作用研究. 信阳师范学院学报(自然科学版). 2018(03): 385-388 . 本站查看
    2. 吴妮妮,马丽,卢奎. BRCA1与Rad51的相互作用研究进展. 中州大学学报. 2017(06): 103-108 . 百度学术

    其他类型引用(1)

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出版历程
  • 收稿日期:  2016-11-01
  • 修回日期:  2017-01-11
  • 发布日期:  2017-04-09

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