Abstract: Monthly rainfall data of 29 meteorological stations in Huaihe River Basin during 1951-2014 was selected for study. Multiple methods, including linear trend, accumulative anomaly, wavelet analysis and spatial analysis, were applied to detect spatial and temporal characteristics of rainfall variations. The results showed that (1) linear trend for annual, spring, summer and autumn precipitation decreased slightly, and the increasing trend for winter rainfall was not as well obvious; (2) more drought and flood events occurred in spring, autumn and winter. Variation of summer precipitation dominated annual rainfall; (3) quasi-periodicity of 2 years and 6 years were detected in annual rainfall; (4) it indicated an decreasing gradient from southeastern to northwestern in Huaihe River Basin, which was similar in pattern with China; (5) variations of annual and summer precipitation at spatial time scale were stronger than other seasons, and regions with increasing rainfall were surrounded by regions with decreasing rainfall. Regional winter precipitation fluctuated with no significant trend during the period of 1951-2014.