Abstract: The working principle and control system of the brushless DC motor with position sensor were introduced. A control and drive system based on TMS320F28335 microcontroller and IR21366 power driving chip was designed. The design scheme and realization of the interface circuit of each part for the system were discussed in details. According to the characteristics of the speed control of Brushless DC motor, the speed regulator and current regulator were designed. The integral separated PID control algorithm was adopted to reduce the speed overshoot effectively. The test results indicated that the system had higher reliability, faster response, and better performance index of control effect.