阿伐那非类似物的合成与表征

Synthesis and Characterization of Avanafil Analogues

摘要: 以4-(3-氯-4-甲氧基苄基氨基)-2-(2S)-2-羟甲基-1-吡咯烷基-5-嘧啶羧酸乙酯为原料,在VDMSO∶VTHF=1∶1的混合溶液中,水解成酸后,与不同的胺反应,合成了8种未见文献报道的阿伐那非类似物.所合成的产物经1HNMR、13CNMR、ESI-MS得到验证 .

Abstract: The 8 kinds of no literature reports of avanafil analogues were synthesized by amidation of amines and hydrolyzate of 4-\(3-chloro-4-methoxybenzyl) amino\-2-\(2S)-2-hydroxymethyl-1-pyrrolidinyl\-5-pyrimidineethyl-formate(1)，which hydrolyzed in mixed solvent(VDMSO∶VTHF=1∶1) . Their structure was characterized by 1H NMR, 13C NMR and ESI-MS.