N-(1-(5-溴-2-((对氯苄基)氧基)苄基)-4-哌啶基)-N-乙基苯甲酰胺的合成及表征
Synthesis and Characterization of N-(1-(5-bromo-2-((4-chlorobenzyl)oxy)benzyl)-4-piperidinyl)-N-ethylbenzamide
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摘要: 以对氯苄氯、5-溴水杨醛为原料，通过消去、还原及溴化合成了4-溴-2-溴甲基-1-((4-氯苄基)氧)苯(Ⅲ)，以1-苄基-4-哌啶酮合成了N-乙基-N-(4-哌啶基）苯甲酰胺(Ⅳ)，通过Ⅲ、Ⅳ反应得到了一种新的非肽类CCR5拮抗N-(1-(5-溴-2-((对氯苄基)氧基）苄基）-4-哌啶基)-N-乙基苯甲酰胺，并对该产物进行了MS、13CNMR及1HNMR表征Abstract: 4-bromo-2-(bromomethyl)-1-((4-chlorobenzyl)oxy)benzene(III) was synthesized from 1-chloro-4- (chloromethyl)benzene and 5-bromo-2-hydroxybenzaldehyde by elimination reaction,reduction reaction and bromization. N-ethyl-N-(4-piperidinyl)benzamide(IV) was prepared from 1-benzylpiperidine-4-one. Further reaction of III with IV gave a novel non-peptide CCR5 antagonist N-(1-(5-bromo-2-((4-chlorobenzyl)oxy)benzyl)-4-piperidyl)-N-ethylbenzoylamide. The structure of these products was characterized by MS, 13CNMR and 1HNMR
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