Abstract: Diacetone alcohol was synthesized by using acetone as raw material, in reaction-distillation installation and under the big-holed anion exchange resin catalyst. The optimum conditions were determined by single-factor and orthogonal experiments. The optimum conditions were: the feed flow rate was 1.58 mL/min, the reaction temperature was 25 ℃，the reaction time was 2 hours.The yield of diacetone alcohol was 80%