Abstract: Systems biology is a biology-based inter-disciplinary field which focuses on complex interactions within biological systems. Systems biological study can integrate multi-dimensional data describing the target biological system at different levels, and establish mathematical models of the system to study the characteristic behaviors of the system by virtual simulation, interference and forecasts. As complex biological systems, cancers have been extensively studied in systems biology. Systems biology models of cancers，including statistics-based models，signaling and metabolic biochemical models and tissue-level models，are valuable supplement to traditional animal models in cancer research. In this review,  some valuable mathematical modeling efforts made in cancer systems biology were overviewed.