Abstract: Serum amyloid A1 is an acute phase reaction protein secreted by the liver,which rises rapidly in plasma after inflammation,trauma or infection.The recombinant human serum amyloid A1-β subtype expressed by prokaryotic vector pET28a-SAA1-β.The SAA1-β protein was purified and identified by Western Blot.Meanwhile,SAA1-β protein was co-cultured with Candida albicans SC5314 to detect its effect on the growth of SC5314.The results showed that when the protein concentration was 0、2、20、200 mg/L,the average number of colonies was 423,385,262 and 217,and the bacteriostasis rates were 0%、8.98%、38.06% and 48.70%,respectively.The results showed that SAA1-β protein concentration in the range of 200 mg/L had a good inhibitory effect on Candida albicans SC5314,and the inhibition was positively correlated with the protein concentration.