Abstract: This work developed an efficient method for the synthesis of 2-amino-7,7-dimethyl-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile derivatives from aromatic aldehydes or isatins,5,5-dimethylcyclohexane-1,3-dione and malononitrile.The desired products were obtained with high yields in ethanol at room temperature,and structure of all compounds were characterized by 1HNMR,13CNMR and elemental analysis.The results showed that this method had advantages of mild reaction conditions,simple operation,convenient post-processing,high yield,and environment-friendly.