Abstract: C57BL/6 mice were randomly divided into two groups.The mice in experimental group were given intraperitoneal injection of pilocarpine (PILO) to evoke status epilepticus (SE), and the mice in control group were given saline with the same volume. Auditory capacities of mice were tested at 4 weeks after the onset of SE, and to investigate effects of Mozart K.448 on high frequency electroencephalogram (EEG) activities at spontaneous recurrent seizure state in temporal lobe epilepsy model mice. Mozart K.448 was played at 6 to 7 weeks after the onset of SE.  According to experimental data, PILO-injected not affect auditory capacities of mice significantly and Mozart K.448 therapy enhanced EEG activity at frequencies between 55 Hz to 145 Hz both in control and SE model mice . The results showed that short-term playing of Mozart K.448 enhanced high frequency EEG activities